During its use as a royal estate, it is estimated that about 750 people lived there, with most serving as support staff (yanaconas, yana) who lived there permanently. Though the estate belonged to Pachacutec, religious specialists and temporary specialized workers (mayocs) lived there as well, most likely for the ruler's well-being and enjoyment. During the harsher season, staff dropped down to around a hundred servants and a few religious specialists focused on maintenance alone.
Studies show that, according to their skeletal remains, most people who lived there were immigrants from diverse backgrounds. They lacked the chemical markers and osteological markers they would have if they had been living there their whole lives. Instead, there was bone damage from various species of water parasites indigenous to different areas of Peru. There were also varying osteological stressors and varying chemical densities suggesting varying long-term diets characteristic of specific regions that were spaced apart. These diets are composed of varying levels of maize, potatoes, grains, legumes, and fish, but the overall most recent short-term diet for these people was composed of less fish and more corn. This suggests that several of the immigrants were from more coastal areas and moved to Machu Picchu where corn was a larger portion of food intake. Most skeletal remains found at the site had lower levels of arthritis and bone fractures than those found in most sites of the Inca Empire. Inca individuals who had arthritis and bone fractures were typically those who performed heavy physical labor (such as the Mit'a) or served in the Inca military.
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